Respiratory Immunopharmacology Group
Focused on studies investigating mechanisms of inflammation, tissue damage and repair in respiratory diseases
Respiratory Immunopharmacology Group
The respiratory immunopharmacology research group is focused on studies investigating mechanisms of inflammation, tissue damage and repair in respiratory diseases, including cystic fibrosis (CF), non-cystic fibrosis bronchiectasis (NCFBE), asthma and chronic obstructive pulmonary disease (COPD).
The group is lead by Professor Janis Shute.
Asthma research focuses on mechanisms of bronchial epithelial repair and, in particular, the role of coagulation factors and fibrin formation in models of epithelial wounding. In addition, the group are developing disease biomarker assays to monitor disease progression and response to therapy in clinical samples obtained non-invasively.
The destruction of collagen and elastin by neutrophil elastase plays a central role in th